I agree with Melissa Tuchscherer that 'Duchscherer' or 'Tuchscherer' (variants of the same name) have an origin in the German 'tailor' or more literally 'Duch/Tuch'/cloth + 'scherer'/cutter. The names Dukeshier and Dukeshire are evidently more recent variants of the original 'Tuchscherer', altered in the new world, in Nova Scotia, Canada. From what I understand, some of group (whether Duchscherer, Tuchscherer, etc.) first immigrated to the United States around the time of the American Revolution, as mercenaries fighting for the British against the American colonists. Many of these people stayed in what would become the USA, others went to Canada -- and the spelling conventions changed.
Some Tuchscherers came later. I have only recently learned that my anscestors, the Tuchscherers, immigrated in the 1850s from Nassau, a sovereign 'Dutchy' from 1806-1866 of what is today the nation of Germany. This wave of Tuchscherers landed in Wisconsin. Why this is, I have no idea. Many of these Tuchscherers, all descended from the original Jacob Tuchscherer, have spread out all over the country.