I have a little more info on Isaac Kizer -- came to VA from Germany in the 1770s. He had a son, Nicholas Kizer, in 1801. Nicholas married Elizabeth Boyle in 1834, they had at least one child (Marion Kizer, b. 1838) while residing somewhere in Iowa, and moved to Oregon in 1853.
I wasn't previously aware of what part of VA Isaac had resided -- thank you!
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