There was only but one Lock family that I am aware of who made this migration on the Oregon Trail in that time era.
That is the descendants of Abraham Lock of Chariton County Missouri. I believe 3 of his sons made this trip to Oregon, so it seems likely this is the family you are seeking.
I have never seen the name Margaret Willow Lock before, so I will have to do some digging just to see if she does belong to Abraham Lock's lineage.
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